Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.51 |
| ▸ | FNTB | P49356 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29465057 | 0.88 | TSHR (0.61) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29465023 | 0.85 | SIGMAR1 (0.51) | PLAURTSHRRECQL | |
| SCHEMBL29857012 | 0.84 | L3MBTL3 (0.49) | TSHRLMNARAB9ARECQL | |
| SCHEMBL19815809 | 0.84 | L3MBTL1 (0.55) | ALDH1A1CYP2C9TSHRLMNASMN1; SMN2 | |
| SCHEMBL3996738 | 0.79 | TSHR (0.73) | ALDH1A1CYP1A2CYP3A4CYP2C9PLAUR | |
| SCHEMBL29857137 | 0.77 | HRH4 (0.49) | TSHRTP53RECQL | |
| SCHEMBL19817301 | 0.75 | PRKAB2 (0.54) | ALDH1A1KDM4E | |
| SCHEMBL7121916 | 0.73 | SMN1; SMN2 (0.77) | ALDH1A1TSHRGAASMN1; SMN2TP53 | |
| SCHEMBL7885342 | 0.73 | ALDH1A1 (0.57) | ALDH1A1CYP1A2CYP3A4CYP2C9PLAUR | |
| SCHEMBL20181880 | 0.72 | ALDH1A1 (0.75) | ALDH1A1CYP1A2CYP3A4LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3890737-B1 | USP19 INHIBITORS FOR USE IN A METHOD OF TREATING OBESITY, INSULIN RESISTANCE AND TYPE II DIABETES | ALMAC DISCOVERY LTD (GB) | 2024-06-05 | — | — | EP | claimed |
| EP-3490982-A1 | PHARMACEUTICAL COMPOUNDS | Almac Discovery Limited (GB) | 2019-06-05 | — | — | EP | claimed |
| WO-2018020242-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2018-02-01 | — | — | WO | claimed |
| CN-109790146-B | Pharmaceutical compounds | 阿尔麦克探索有限公司 | 2022-08-23 | — | — | CN | disclosed |