Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 3/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860062 | 0.87 | ALDH1A1 (0.61) | PRMT3NOTUMIMPDH2ROCK2LMNA | |
| SCHEMBL19860067 | 0.87 | PRMT3 (0.54) | PRMT3NOTUMIMPDH2ROCK2ROCK1 | |
| SCHEMBL19860040 | 0.87 | PRMT3 (0.53) | PRMT3NOTUMIMPDH2ROCK2ROCK1 | |
| SCHEMBL19860066 | 0.87 | IMPDH2 (0.65) | PRMT3NOTUMIMPDH2NPY5RROCK1 | |
| SCHEMBL20353460 | 0.84 | IMPDH2 (0.71) | PRMT3IMPDH2ROCK2 | |
| SCHEMBL3598327 | 0.83 | PRMT3 (0.56) | PRMT3NOTUMIMPDH2ROCK2 | |
| SCHEMBL3566775 | 0.83 | PRMT3 (0.72) | PRMT3NOTUMIMPDH2ROCK2NPY5R | |
| SCHEMBL16684130 | 0.82 | PRMT3 (0.44) | PRMT3NOTUMIMPDH2ROCK2ROCK1 | |
| SCHEMBL19860079 | 0.82 | ALDH1A1 (0.61) | PRMT3NOTUMIMPDH2ROCK2ROCK1 | |
| SCHEMBL2164137 | 0.81 | PRMT3 (0.69) | PRMT3NOTUMIMPDH2ROCK2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |