Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 2/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860062 | 0.87 | ALDH1A1 (0.61) | PRMT3IMPDH2NOTUMROCK2 | |
| SCHEMBL19860064 | 0.87 | PRMT3 (0.54) | PRMT3IMPDH2NOTUMROCK2ROCK1 | |
| SCHEMBL3566775 | 0.85 | PRMT3 (0.72) | PRMT3IMPDH2NOTUMROCK2ROCK1 | |
| SCHEMBL19860066 | 0.84 | IMPDH2 (0.65) | PRMT3IMPDH2NOTUMROCK1PLAU | |
| SCHEMBL2164137 | 0.82 | PRMT3 (0.69) | PRMT3IMPDH2NOTUMROCK2ROCK1 | |
| SCHEMBL12228149 | 0.82 | NOTUM (0.72) | IMPDH2NOTUMROCK2MEN1KMT2A | |
| SCHEMBL3592528 | 0.82 | GRK2 (0.54) | PRMT3IMPDH2NOTUMROCK2MEN1 | |
| SCHEMBL19860091 | 0.81 | ROCK2 (0.60) | PRMT3IMPDH2NOTUMROCK2 | |
| SCHEMBL19860089 | 0.81 | ROCK2 (0.55) | PRMT3IMPDH2NOTUMROCK2ROCK1 | |
| SCHEMBL19860079 | 0.81 | ALDH1A1 (0.61) | PRMT3IMPDH2NOTUMROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |