Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.65 |
| ▸ | SENP1 | Q9P0U3 | 4/20 | 0.58 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860064 | 0.87 | PRMT3 (0.54) | IMPDH2PRMT3NPY5RLMNAROCK1 | |
| SCHEMBL3566775 | 0.85 | PRMT3 (0.72) | IMPDH2PRMT3NPY5RLMNAROCK1 | |
| SCHEMBL19860067 | 0.84 | PRMT3 (0.54) | IMPDH2PRMT3ROCK1NOTUMPLAU | |
| SCHEMBL2164137 | 0.83 | PRMT3 (0.69) | IMPDH2PRMT3NAMPTNPY5RLMNA | |
| SCHEMBL19860062 | 0.82 | ALDH1A1 (0.61) | IMPDH2PRMT3LMNANOTUMMAPT | |
| SCHEMBL21900830 | 0.81 | NAMPT (0.71) | IMPDH2NAMPTLMNAHDAC3HDAC1 | |
| SCHEMBL19860123 | 0.80 | IMPDH2 (0.71) | IMPDH2PRMT3ROCK1NOTUM | |
| SCHEMBL2162998 | 0.79 | IMPDH2 (1.00) | IMPDH2PRMT3NAMPTROCK1 | |
| SCHEMBL14124401 | 0.79 | IMPDH2 (0.61) | IMPDH2PRMT3NAMPTNPY5RLMNA | |
| SCHEMBL22752080 | 0.79 | JAK2 (0.59) | IMPDH2PRMT3ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |