Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860120 | 0.89 | PRMT3 (0.53) | ALDH1A1HPGDNOTUMROCK2PRMT3 | |
| SCHEMBL19860064 | 0.87 | PRMT3 (0.54) | NOTUMROCK2LMNAPRMT3IMPDH2 | |
| SCHEMBL19860067 | 0.87 | PRMT3 (0.54) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL3587855 | 0.83 | NOTUM (0.55) | ALDH1A1HPGDNOTUMROCK2LMNA | |
| SCHEMBL3566775 | 0.83 | PRMT3 (0.72) | NOTUMROCK2LMNAPRMT3IMPDH2 | |
| SCHEMBL19860066 | 0.82 | IMPDH2 (0.65) | NOTUMLMNAPRMT3IMPDH2MAPT | |
| SCHEMBL19860079 | 0.82 | ALDH1A1 (0.61) | ALDH1A1NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL2164137 | 0.81 | PRMT3 (0.69) | NOTUMROCK2LMNAPRMT3IMPDH2 | |
| SCHEMBL19860091 | 0.80 | ROCK2 (0.60) | NOTUMROCK2PRMT3IMPDH2 | |
| SCHEMBL19860089 | 0.80 | ROCK2 (0.55) | ALDH1A1NOTUMROCK2LMNAPRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |