Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 9/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14124393 | 0.89 | IMPDH2 (0.52) | ALDH1A1PRMT3IMPDH2NOTUMLMNA | |
| SCHEMBL14124408 | 0.85 | TERT (0.53) | ALDH1A1POLBPRMT3IMPDH2NOTUM | |
| SCHEMBL19860085 | 0.83 | TERT (0.64) | SMN1; SMN2ALDH1A1POLBPRMT3IMPDH2 | |
| SCHEMBL19860074 | 0.82 | TERT (0.63) | SMN1; SMN2ALDH1A1POLBPRMT3IMPDH2 | |
| SCHEMBL19860084 | 0.80 | IMPDH2 (0.55) | SMN1; SMN2ALDH1A1PRMT3IMPDH2NOTUM | |
| SCHEMBL2162496 | 0.80 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL19860073 | 0.78 | IMPDH2 (0.53) | ALDH1A1PRMT3IMPDH2NOTUMLMNA | |
| SCHEMBL13102889 | 0.78 | SMN1; SMN2 (0.79) | SMN1; SMN2ALDH1A1POLBTSHR | |
| SCHEMBL19860076 | 0.76 | LMNA (0.61) | SMN1; SMN2ALDH1A1POLBIMPDH2LMNA | |
| SCHEMBL19860086 | 0.76 | GSK3B (0.58) | SMN1; SMN2ALDH1A1PRMT3IMPDH2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |