Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 6/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14124394 | 0.85 | IMPDH2 (0.53) | NPC1PRMT3IMPDH2NOTUM | |
| SCHEMBL19860124 | 0.83 | IMPDH2 (0.59) | PRMT3IMPDH2KDM4EALDH1A1NOTUM | |
| SCHEMBL2162616 | 0.81 | IMPDH2 (0.70) | PRMT3IMPDH2KDM4EALDH1A1MAPT | |
| SCHEMBL19860110 | 0.81 | IMPDH2 (0.59) | PRMT3IMPDH2NOTUM | |
| SCHEMBL19860109 | 0.80 | PRMT3 (0.50) | PRMT3IMPDH2NOTUM | |
| SCHEMBL19860111 | 0.79 | NOTUM (0.55) | PRMT3IMPDH2KDM4EALDH1A1NOTUM | |
| SCHEMBL19860105 | 0.78 | PRMT3 (0.62) | PRMT3IMPDH2NOTUM | |
| SCHEMBL19860043 | 0.78 | NOTUM (0.63) | NPC1PRMT3IMPDH2KDM4EALDH1A1 | |
| SCHEMBL19860106 | 0.77 | ROCK1 (0.57) | MEN1KMT2APRMT3IMPDH2NOTUM | |
| SCHEMBL14124375 | 0.77 | ROCK1 (0.59) | PRMT3IMPDH2LMNANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |