Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.57 |
| ▸ | PRMT3 | O60678 | 3/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14136014 | 0.89 | LMNA (0.67) | MEN1KMT2AROCK2PRMT3IMPDH2 | |
| SCHEMBL14124377 | 0.89 | PRMT3 (0.51) | MEN1KMT2AROCK2PRMT3IMPDH2 | |
| SCHEMBL19860124 | 0.88 | IMPDH2 (0.59) | PRMT3IMPDH2ALDH1A1NOTUMKDM4E | |
| SCHEMBL2162395 | 0.88 | ROCK2 (0.61) | MEN1KMT2AROCK2PRMT3IMPDH2 | |
| SCHEMBL19860106 | 0.86 | ROCK1 (0.57) | MEN1KMT2AROCK2PRMT3IMPDH2 | |
| SCHEMBL19860093 | 0.86 | ROCK2 (0.61) | MEN1KMT2AROCK2PRMT3IMPDH2 | |
| SCHEMBL2162616 | 0.86 | IMPDH2 (0.70) | ROCK2PRMT3IMPDH2ALDH1A1NOTUM | |
| SCHEMBL3593343 | 0.86 | ACHE (0.61) | ROCK2PRMT3IMPDH2NOTUM | |
| SCHEMBL19860110 | 0.83 | IMPDH2 (0.59) | ROCK2PRMT3IMPDH2L3MBTL1NOTUM | |
| SCHEMBL19860105 | 0.81 | PRMT3 (0.62) | PRMT3IMPDH2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890123-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |