SCHEMBL19862624

SCHEMBL19862624

Cc1ccc(C2CC(=O)NC2(C)C)cc1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.43
GAA P10253 1/20 0.43
ALDH1A1 P00352 5/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
SIRT1 Q96EB6 1/20 0.38
THRB P10828 2/20 0.38
MAPT P10636 3/20 0.37
ATM Q13315 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
MAP1LC3B Q9GZQ8 1/20 0.35
DDB1 Q16531 1/20 0.35
CRBN Q96SW2 1/20 0.35
HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26976730 0.84 GSK3B (0.43) SMN1; SMN2GAAALDH1A1CYP2C19NPSR1
SCHEMBL26976667 0.84 LMNA (0.43) SMN1; SMN2GAACYP3A4CYP2C9MAPT
SCHEMBL26976689 0.84 LIG1 (0.42) SMN1; SMN2GAAALDH1A1MEN1KMT2A
SCHEMBL18590510 0.84 SMN1; SMN2 (0.50) SMN1; SMN2GAAALDH1A1MEN1KMT2A
SCHEMBL26976625 0.84 SMN1; SMN2 (0.50) SMN1; SMN2GAAALDH1A1MEN1KMT2A
SCHEMBL26976946 0.83 CRBN (0.43) SMN1; SMN2GAAALDH1A1MEN1KMT2A
SCHEMBL26976633 0.81 DDB1 (0.48) SMN1; SMN2GAAALDH1A1MEN1KMT2A
SCHEMBL26976903 0.80 CYP3A4 (0.43) SMN1; SMN2GAAMEN1KMT2ACYP3A4
SCHEMBL26976795 0.80 L3MBTL1 (0.44) SMN1; SMN2GAAMEN1KMT2ACYP3A4
SCHEMBL19862623 0.78 SMN1; SMN2 (0.40) SMN1; SMN2GAAALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240188565-A1 GLOBODERA PALLIDA CONTROL AGENT NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION (JP) 2024-06-13 US claimed
EP-4298907-A1 GLOBODERA PALLIDA CONTROL AGENT NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION (JP) 2024-01-03 EP claimed
WO-2022181170-A1 GLOBODERA PALLIDA CONTROL AGENT 国立研究開発法人農業・食品産業技術総合研究機構 2022-09-01 WO claimed
US-20240188565-A1 GLOBODERA PALLIDA CONTROL AGENT NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION (JP) 2024-06-13 US disclosed
EP-4298907-A1 GLOBODERA PALLIDA CONTROL AGENT NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION (JP) 2024-01-03 EP disclosed
WO-2022181170-A1 GLOBODERA PALLIDA CONTROL AGENT 国立研究開発法人農業・食品産業技術総合研究機構 2022-09-01 WO disclosed
US-10029983-B2 Urea derivative or pharmacologically acceptable salt thereof KYORIN PHARMACEUTICAL CO., LTD. (JP) 2018-07-24 US disclosed
US-20180044290-A1 UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF KYORIN SEIYAKU KK (JP) 2018-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240188565-A1 GLOBODERA PALLIDA CONTROL AGENT GHRHR, BRIX1, RBX1 SMN1; SMN2 322/4885GAA 549/4885ALDH1A1 1542/4885
US-10029983-B2 Urea derivative or pharmacologically acceptable salt thereof FPR1, FPR2, FPR3 SMN1; SMN2 3809/4885GAA 3976/4885ALDH1A1 2202/4885
US-20180044290-A1 UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF FPR1, FPR2, FPR3 SMN1; SMN2 3809/4885GAA 3976/4885ALDH1A1 2202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.