SCHEMBL198786

SCHEMBL198786

O=C(O)c1c(F)cc(O)cc1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR1 Q9BXC0 3/20 0.48
CYP3A4 P08684 3/20 0.46
ACHE P22303 1/20 0.46
CA1 P00915 5/20 0.46
CA12 O43570 4/20 0.46
CA9 Q16790 4/20 0.46
CA2 P00918 4/20 0.46
CA7 P43166 3/20 0.46
CA14 Q9ULX7 3/20 0.46
MIF P14174 1/20 0.39
PTPN1 P18031 1/20 0.39
PTPN11 Q06124 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
HPGD P15428 3/20 0.39
HSD17B10 Q99714 3/20 0.39
KDM4E B2RXH2 2/20 0.39
LMNA P02545 2/20 0.39
CA4 P22748 2/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPK1 P28482 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23601107 0.84 HCAR1 (0.41) HCAR1CYP3A4ACHECA1CA12
SCHEMBL27112161 0.84 HCAR1 (0.41) HCAR1CYP3A4ACHECA1CA12
SCHEMBL288979 0.81 CES2 (0.46) HCAR1CA1CA2HPGDHSD17B10
SCHEMBL28888036 0.81 AKR1C2 (0.45) HCAR1CA1CA12CA9CA2
SCHEMBL542833 0.79 LMNA (0.50) HCAR1CA1CA12CA9CA2
SCHEMBL29154306 0.79 CES2 (0.44) HCAR1CA1CA2HPGDHSD17B10
SCHEMBL17177745 0.79 AKR1C2 (0.44) HCAR1CA1CA12CA9CA2
SCHEMBL29025457 0.78 ESR1 (0.44) MIF
SCHEMBL257644 0.77 CA1 (0.34) HCAR1CYP3A4ACHECA1CA12
SCHEMBL3031058 0.77 TPMT (0.48) HCAR1CYP3A4HPGDHSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 180 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116178685-A LCP material with high clearing point and preparation method thereof 宁夏清研高分子新材料有限公司 2023-05-30 CN claimed
CN-113004694-A Organic silicon material capable of being ceramized and preparation method thereof 西南科技大学 2021-06-22 CN claimed
JP-10265442-A None JP disclosed
US-20260125362-A1 TARGETED PROTEIN DEGRADATION OF PARP14 FOR USE IN THERAPY ABBVIE BIOTECHNOLOGY LTD (BM) 2026-05-07 US disclosed
US-20250282781-A1 APOL1 INHIBITORS AND METHODS OF USE HERCULES CAPITAL, INC., AS AGENT 2025-09-11 US disclosed
US-12344610-B2 APOL1 inhibitors and methods of use MAZE THERAPEUTICS, INC. (US) 2025-07-01 US disclosed
CN-119463143-A Polynaphthalate resin and preparation method thereof 四川大学 2025-02-18 CN disclosed
CN-111699176-B Quinazolinones as PARP14 inhibitors 里邦医疗公司 2025-02-14 CN disclosed
US-20240400565-A1 APOL1 INHIBITORS AND METHODS OF USE HERCULES CAPITAL, INC., AS AGENT 2024-12-05 US disclosed
WO-2024249254-A2 METHODS OF USING APOL1 INHIBITORS MAZE THERAPEUTICS, INC. (US) 2024-12-05 WO disclosed
EP-4465982-A2 APOL1 INHIBITORS AND METHODS OF USE Maze Therapeutics, Inc. (US) 2024-11-27 EP disclosed
CN-1441031-A Liquid crystal polyester resin composition for connector SUMITOMO CHEMICAL CO (JP) 2003-09-10 CN disclosed
US-6512079-B2 Acylating aromatic diol and/or aromatic hydroxycarboxylic acid with fatty anhydride, then transesterifying, in presence of imidazole based compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-01-28 US disclosed
US-20020143135-A1 Process for producing aromatic liquid crystal polyester SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-10-03 US disclosed
US-20020055607-A1 Liquid crystalline polyester and method for producing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-09 US disclosed
EP-1184401-A1 Liquid crystalline polyester and method for producing the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-03-06 EP disclosed
JP-H10265442-A DIFLUOROBENZOIC ACID DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP 1998-10-06 JP disclosed
US-4857626-A OPTICAL,ANISOTROPIC POLYMERS; HEAT RESISTANCE MOLDING MATERIALS MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) 1989-08-15 US disclosed
US-4814417-A Process for producing a liquid crystalline polyester polymer of a cyclohexanedicarboxylic acid and an aromatic diol with pyridine/thionyl chloride catalyst CHISSO CORPORATION (JP) 1989-03-21 US disclosed
EP-0272676-A2 Wholly aromatic polyester and process for its production Mitsubishi Chemical Corporation (JP) 1988-06-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12344610-B2 APOL1 inhibitors and methods of use APOL1, APOB, PON1 HCAR1 3141/4885CYP3A4 1340/4885ACHE 1476/4885
US-20260125362-A1 TARGETED PROTEIN DEGRADATION OF PARP14 FOR USE IN THERAPY PARP14, PARP16, PARP11 HCAR1 805/4885CYP3A4 2737/4885ACHE 4865/4885
US-20250282781-A1 APOL1 INHIBITORS AND METHODS OF USE APOL1, APOB, PON1 HCAR1 3141/4885CYP3A4 1340/4885ACHE 1476/4885
US-20240400565-A1 APOL1 INHIBITORS AND METHODS OF USE APOL1, APOB, PON1 HCAR1 3141/4885CYP3A4 1340/4885ACHE 1476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.