Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.47 |
| ▸ | CA1 | P00915 | 9/20 | 0.47 |
| ▸ | CA12 | O43570 | 6/20 | 0.46 |
| ▸ | CA9 | Q16790 | 6/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TIMP3 | P35625 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1988912 | 1.00 | CA2 (0.47) | CA2CA1CA12CA9CA14 | |
| SCHEMBL31020737 | 0.86 | ALDH1A1 (0.55) | CA2CA1CA12CA9CA14 | |
| SCHEMBL30644158 | 0.81 | PKM (0.57) | CA2CA1CA12CA9CA14 | |
| SCHEMBL8761539 | 0.81 | TDP1 (0.46) | CA2CA1CA12CA9ALDH1A1 | |
| SCHEMBL18880246 | 0.79 | LMNA (0.45) | CA2CA1CA12CA9CA14 | |
| SCHEMBL11565258 | 0.79 | CA12 (0.47) | CA2CA1CA12CA9ADAMTS4 | |
| SCHEMBL2584998 | 0.79 | TDP1 (0.54) | CA12CA9ADAMTS4ALDH1A1TSHR | |
| SCHEMBL27999251 | 0.79 | KEAP1 (0.52) | CA2CA1CA12CA9ALDH1A1 | |
| SCHEMBL3078749 | 0.77 | CA12 (0.50) | CA1CA12ALDH1A1SMN1; SMN2 | |
| SCHEMBL7028109 | 0.77 | CA12 (0.47) | CA2CA1CA12CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788149-A1 | A METHOD FOR OPTIMIZING ANTIBODY EXPRESSION | Ambrx, Inc. (US) | 2021-03-10 | — | — | EP | claimed |
| EP-2337846-B1 | NON-NATURAL AMINO ACID REPLICATION-DEPENDENT MICROORGANISMS AND VACCINES | AMBRX INC (US) | 2018-01-17 | — | — | EP | claimed |
| EP-2337846-A1 | NON-NATURAL AMINO ACID REPLICATION-DEPENDENT MICROORGANISMS AND VACCINES | Ambrx, Inc. (US) | 2011-06-29 | — | — | EP | disclosed |
| WO-2010037062-A1 | NON-NATURAL AMINO ACID REPLICATION-DEPENDENT MICROORGANISMS AND VACCINES | AMBRX, INC. (US) | 2010-04-01 | — | — | WO | disclosed |