Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 2/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | PAM | P19021 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270681 | 0.92 | CTRB1 (0.58) | CTRB1LMNANPC1RAB9AREN | |
| SCHEMBL24078873 | 0.88 | CTRB1 (0.58) | CTRB1LMNANPC1RAB9ACTSS | |
| SCHEMBL7279589 | 0.83 | CA2 (0.56) | REN | |
| SCHEMBL7442013 | 0.82 | CTRB1 (0.55) | CTRB1LMNANPC1RAB9ACTSS | |
| SCHEMBL14570232 | 0.82 | CTRB1 (0.55) | CTRB1LMNANPC1RAB9ACTSS | |
| SCHEMBL7434134 | 0.82 | CTRB1 (0.55) | CTRB1LMNANPC1RAB9ACTSS | |
| SCHEMBL9535103 | 0.82 | MTNR1A (0.55) | CTRB1LMNARENCTSSCTSK | |
| SCHEMBL14866005 | 0.81 | CTRB1 (0.54) | CTRB1LMNANPC1RAB9ACTSS | |
| SCHEMBL7270640 | 0.80 | KLK5 (0.60) | CTRB1LMNACTSSCTSK | |
| SCHEMBL7364425 | 0.80 | CTSD (0.56) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9913834-B2 | Bis-benzylidine piperidone proteasome inhibitor with anticancer activity | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-03-13 | — | — | US | disclosed |