SCHEMBL1995536

SCHEMBL1995536

O=COc1c(F)c(F)cc(F)c1F

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
CA1 P00915 3/20 0.34
CA2 P00918 3/20 0.34
CA4 P22748 2/20 0.34
CA12 O43570 1/20 0.34
CA7 P43166 1/20 0.34
CA13 Q8N1Q1 1/20 0.34
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL392504 0.78 CA1 (0.36) CA1CA2
SCHEMBL1997466 0.78 CES2 (0.38) CES2CES1
SCHEMBL23387001 0.75 CA1 (0.30) CA1CA2CA4CA12CA7
SCHEMBL1343625 0.75 ALDH1A1 (0.33) ALDH1A1CA1CA2CA4CA12
SCHEMBL97201 0.75 CES2 (0.37) CA1CA2CA4CA12CA7
SCHEMBL3182645 0.75 ERN1 (0.40) CES2CES1
SCHEMBL5704438 0.73 ALDH1A1 (0.39) ALDH1A1
SCHEMBL16469385 0.71 MAPT (0.32) MAPT
SCHEMBL16546180 0.71 ERN1 (0.32)
SCHEMBL474389 0.71 INPPL1 (0.32) CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
EP-4397672-A1 COMPOUND AND LABELED BIOMATERIAL USING SAME FUJIFILM Corporation (JP) 2024-07-10 EP disclosed
US-12018159-B2 Ultra bright dimeric or polymeric dyes and methods for preparation of the same Sony Group Corporation (JP) 2024-06-25 US disclosed
US-11827661-B2 Water soluble fluorescent or colored dyes comprising conjugating groups Sony Group Corporation (JP) 2023-11-28 US disclosed
US-20220001022-A1 Immunoconjugates Targeting HER2 BOLT BIOTHERAPEUTICS, INC. (US) 2022-01-06 US disclosed
US-11110178-B2 Antibody adjuvant conjugates THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY (US) 2021-09-07 US disclosed
US-20210170043-A1 DC-SIGN ANTIBODY CONJUGATES COMPRISING STING AGONISTS CHINOOK THERAPEUTICS, INC. 2021-06-10 US disclosed
US-20200206357-A1 ANTIBODY ADJUVANT CONJUGATES BOLT BIOTHERAPEUTICS, INC. 2020-07-02 US disclosed
US-10675358-B2 Antibody adjuvant conjugates THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2020-06-09 US disclosed
US-10464969-B2 Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase NOVARTIS AG (CH) 2019-11-05 US disclosed
US-20190144504-A1 AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. 2019-05-16 US disclosed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US disclosed
US-8748097-B1 Identification of agents for treating calcium disorders and uses thereof PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2014-06-10 US disclosed
US-8747535-B1 Solid ink compositions comprising crystalline-amorphous mixtures XEROX CORPORATION (US) 2014-06-10 US disclosed
CN-102186921-B Fluorine-containing copolymer composition and process for production thereof ASAHI GLASS CO LTD 2014-01-15 CN disclosed
EP-2338935-B1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS CO LTD (JP) 2012-12-12 EP disclosed
CN-102186921-A Fluorine-containing copolymer composition and process for production thereof ASAHI GLASS CO LTD 2011-09-14 CN disclosed
US-20110172336-A1 FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS ASAHI GLASS COMPANY, LIMITED (JP) 2011-07-14 US disclosed
EP-2338935-A1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS COMPANY, LIMITED (JP) 2011-06-29 EP disclosed
US-20070299204-A1 Polymerizable Composition for Forming Optical Device, Optical Device and Method for Producing Optical Device FUJIFILM CORPORATION (JP) 2007-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10464969-B2 Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase RNGTT, RNASE1, RNMT ALDH1A1 3142/4885CA1 2515/4885CA2 3395/4885
US-20200206357-A1 ANTIBODY ADJUVANT CONJUGATES FCGR1A, FCGR3B, FCGR2A ALDH1A1 978/4885CA1 1037/4885CA2 2977/4885
US-10675358-B2 Antibody adjuvant conjugates FCGR1A, FCGR3B, FCGR2A ALDH1A1 978/4885CA1 1037/4885CA2 2977/4885
US-20210170043-A1 DC-SIGN ANTIBODY CONJUGATES COMPRISING STING AGONISTS STING1, TLR9, TLR3 ALDH1A1 4425/4885CA1 4619/4885CA2 4384/4885
US-20190144504-A1 AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE RNGTT, RNASE1, RNMT ALDH1A1 3142/4885CA1 2515/4885CA2 3395/4885
US-11827661-B2 Water soluble fluorescent or colored dyes comprising conjugating groups CHRM1, CHRM2, H1-0 ALDH1A1 965/4885CA1 2197/4885CA2 3774/4885
US-20220001022-A1 Immunoconjugates Targeting HER2 ERBB2, EGFR, FCGR2A ALDH1A1 4387/4885CA1 1407/4885CA2 405/4885
US-11110178-B2 Antibody adjuvant conjugates FCGR1A, FCGR3B, FCGR2A ALDH1A1 978/4885CA1 1037/4885CA2 2977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.