Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 3/20 | 0.52 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | CFD | P00746 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18076580 | 0.86 | PTGER4 (0.61) | PTGER4PTGER3MRGPRX4NR4A2DHODH | |
| SCHEMBL18075742 | 0.81 | PTGER4 (0.50) | PTGER4PTGER3MRGPRX4PPARGJAK2 | |
| SCHEMBL1008116 | 0.80 | LTB4R (0.61) | PPARGNR4A2SMPD1MAOB | |
| SCHEMBL491380 | 0.78 | PPARG (0.51) | MRGPRX4PPARGPRMT5NR4A2 | |
| SCHEMBL18076563 | 0.78 | CYP4F2 (0.59) | PTGER4PTGER3MRGPRX4NR4A2DHODH | |
| SCHEMBL19961835 | 0.77 | MRGPRX4 (0.53) | PTGER4PTGER3MRGPRX4NR4A2DHODH | |
| SCHEMBL11965263 | 0.77 | NR1H4 (0.53) | PPARGPRMT5MAOB | |
| SCHEMBL16624694 | 0.76 | NR1H2 (0.52) | PPARGPRMT5DHODHJAK2JAK3 | |
| SCHEMBL6862344 | 0.76 | L3MBTL1 (0.49) | PPARGDHODH | |
| SCHEMBL3911336 | 0.76 | MRGPRX4 (0.62) | MRGPRX4PPARGNR4A2SMPD1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3271320-B1 | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS | VECTUS BIOSYSTEMS LTD (AU) | 2019-10-23 | — | — | EP | disclosed |
| US-10035775-B2 | Compositions for the treatment of fibrosis and fibrosis-related conditions | VECTUS BIOSYSTEMS LIMITED (AU) | 2018-07-31 | — | — | US | disclosed |
| US-20180072682-A1 | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS | VECTUS BIOSYSTEMS LIMITED (AU) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035775-B2 | Compositions for the treatment of fibrosis and fibrosis-related conditions | MMP1, COL1A1, COL2A1 | PTGER4 616/4885PTGER3 644/4885MRGPRX4 456/4885 |
| US-20180072682-A1 | COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS | MMP1, COL1A1, COL2A1 | PTGER4 616/4885PTGER3 644/4885MRGPRX4 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.