Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533257 | 1.00 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL16992178 | 0.95 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL2824467 | 0.84 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL3169796 | 0.84 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL6806462 | 0.81 | L3MBTL3 (0.41) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL2484748 | 0.81 | SLC6A1 (0.42) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL1419834 | 0.80 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL27145812 | 0.80 | GABRA5 (0.36) | SMN1; SMN2GABRPGABRDGABRA1TSHR | |
| SCHEMBL22130580 | 0.80 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL18241087 | 0.79 | L3MBTL1 (0.39) | NPC1RAB9ASMN1; SMN2POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515897-A1 | PIPERAZINE CARBAMATES AND METHODS OF MAKING AND USING SAME | Abide Therapeutics, Inc. (US) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018053447-A1 | PIPERAZINE CARBAMATES AND METHODS OF MAKING AND USING SAME | ABIDE THERAPEUTICS, INC. (US) | 2018-03-22 | — | — | WO | disclosed |