Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | RECQL | P46063 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980141 | 1.00 | STAT3 (0.32) | STAT3KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL22048699 | 0.83 | KDM4E (0.41) | STAT3KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL20344614 | 0.83 | STAT3 (0.31) | STAT3KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL20344524 | 0.80 | KIF11 (0.40) | MEN1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL19980121 | 0.79 | SLC6A2 (0.40) | KDM4EALDH1A1POLBMAPTNPSR1 | |
| SCHEMBL19980350 | 0.79 | SLC6A2 (0.40) | KDM4EALDH1A1POLBMAPTNPSR1 | |
| SCHEMBL20344472 | 0.75 | STAT3 (0.33) | STAT3KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL19980301 | 0.74 | CCR5 (0.33) | POLB | |
| SCHEMBL25899811 | 0.73 | STAT3 (0.35) | STAT3KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL20615440 | 0.73 | CHRNB2 (0.41) | MEN1POLBKMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |