Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983863 | 0.87 | GPR84 (0.38) | PTGS2TDO2CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL19984195 | 0.85 | LRRK2 (0.41) | PTGS2CHRNB2CHRNA7CHRNA4GRM4 | |
| SCHEMBL19983828 | 0.84 | LMNA (0.38) | CHRNB2CHRNA7CHRNA4GRM4GPR84 | |
| SCHEMBL19983771 | 0.83 | CHRNB2 (0.38) | PTGS2CHRNB2CHRNA7CHRNA4GPR84 | |
| SCHEMBL19983861 | 0.83 | GPR84 (0.41) | PTGS2CHRNB2CHRNA7CHRNA4GRM4 | |
| SCHEMBL19984194 | 0.81 | GPR84 (0.39) | PTGS2CHRNB2CHRNA7CHRNA4GRM4 | |
| SCHEMBL19983904 | 0.81 | GRM4 (0.45) | GRM4ALDH1A1KDR | |
| SCHEMBL19984142 | 0.81 | BACE1 (0.39) | GRM4GPR84 | |
| SCHEMBL19983890 | 0.81 | EGFR (0.43) | CHRNB2CHRNA7CHRNA4GRM4GPR84 | |
| SCHEMBL19984015 | 0.81 | GRM4 (0.39) | TDO2CHRNB2CHRNA7CHRNA4GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |