Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 2/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984147 | 0.88 | CYP2D6 (0.36) | CHRNB2CHRNA7CHRNA4PTK6EGFR | |
| SCHEMBL19983728 | 0.85 | CHRNB2 (0.39) | CHRNB2CHRNA7CHRNA4PTK6GPR84 | |
| SCHEMBL19984195 | 0.85 | LRRK2 (0.41) | CHRNB2CHRNA7CHRNA4IMPDH2HTR2A | |
| SCHEMBL19983880 | 0.79 | MEN1 (0.36) | CHRNB2CHRNA7CHRNA4GPR84HTR2A | |
| SCHEMBL19983903 | 0.78 | CYP2D6 (0.39) | CHRNB2CHRNA7CHRNA4GPR84APP | |
| SCHEMBL19983877 | 0.78 | GPR84 (0.36) | CHRNB2CHRNA7CHRNA4GPR84HTR2A | |
| SCHEMBL19984013 | 0.75 | HTR2A (0.35) | CHRNB2CHRNA7CHRNA4HTR2AMEN1 | |
| SCHEMBL19983831 | 0.75 | HTR2A (0.49) | GPR84HTR2AMEN1KMT2AKDM4E | |
| SCHEMBL19983892 | 0.75 | PTGS2 (0.46) | CHRNB2CHRNA7CHRNA4GPR84HTR2A | |
| SCHEMBL19983890 | 0.74 | EGFR (0.43) | CHRNB2CHRNA7CHRNA4ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |