Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.32 |
| ▸ | MICA | Q29983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16618617 | 0.83 | HDAC1 (0.39) | CYP3A4CYP2D6CYP2C9CYP2C19KIT | |
| SCHEMBL19983961 | 0.82 | DHODH (0.37) | NAMPTKDR | |
| SCHEMBL19983939 | 0.81 | ABL1 (0.37) | KITGPBAR1KDR | |
| SCHEMBL19984057 | 0.78 | AKR1C3 (0.35) | CYP3A4CYP2D6CYP2C9CYP2C19LRRK2 | |
| SCHEMBL16619188 | 0.73 | LMNA (0.40) | LRRK2LMNANAMPTKDR | |
| SCHEMBL16618817 | 0.72 | HDAC1 (0.41) | LMNAMAPTNAMPT | |
| SCHEMBL19984171 | 0.71 | POLB (0.37) | KDM4EEGFRNAMPTPOLB | |
| SCHEMBL19984135 | 0.70 | BCL6 (0.40) | LMNAMAPTKDM4EEGFRSRC | |
| SCHEMBL17971590 | 0.70 | FBP1 (0.47) | LMNAPOLB | |
| SCHEMBL19983733 | 0.70 | SLC6A2 (0.37) | CYP2D6CYP2C9CYP2C19MAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |