Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | SLC20A2 | Q08357 | 1/20 | 0.33 |
| ▸ | SLC20A1 | Q8WUM9 | 1/20 | 0.33 |
| ▸ | YAP1 | P46937 | 1/20 | 0.33 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.33 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19984219 | 0.85 | SLC6A2 (0.36) | NPC1MAPTAPP | |
| SCHEMBL16619023 | 0.84 | HDAC1 (0.43) | AKR1C3AKR1C2NPC1MAPTMPO | |
| SCHEMBL19984289 | 0.80 | NR1I2 (0.39) | NPC1MAPTAPPKDRMAPK14 | |
| SCHEMBL19984191 | 0.78 | CYP3A4 (0.40) | MAPTMPOCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16618751 | 0.74 | SLC20A2 (0.43) | AKR1C3AKR1C2NPC1MAPTMPO | |
| SCHEMBL16618626 | 0.73 | HDAC1 (0.40) | MEN1KMT2A | |
| SCHEMBL19984020 | 0.72 | MTNR1A (0.33) | — | |
| SCHEMBL19983902 | 0.72 | MTNR1A (0.33) | NPC1KMT2A | |
| SCHEMBL16619006 | 0.71 | RORC (0.40) | AKR1C3AKR1C2NPC1MAPTPPARG | |
| SCHEMBL16618638 | 0.71 | HTR6 (0.42) | MAPTAPPSLC20A2SLC20A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |