SCHEMBL19985751

SCHEMBL19985751

C[Si](C)(C)O[Si](O[Si](C)(C)C)(c1ccc(Oc2ccccc2)cc1)c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 8/20 0.48
TSHR P16473 1/20 0.48
NR1H2 P55055 1/20 0.43
BAX Q07812 1/20 0.43
MAOA P21397 1/20 0.43
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
KMT2A Q03164 1/20 0.40
NLRP3 Q96P20 1/20 0.40
TLR8 Q9NR97 1/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
PGR P06401 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21174882 0.83 LTA4H (0.48) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL94228 0.83 ESR1 (0.39) TSHRNR1H2
SCHEMBL16521498 0.81 ESR1 (0.38) TSHRNR1H2MEN1KMT2A
SCHEMBL8992173 0.81 ESR1 (0.38) TSHRNR1H2MEN1KMT2A
SCHEMBL18096779 0.79 LTA4H (0.58) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL10945038 0.79 LTA4H (0.57) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL8954924 0.79 LTA4H (0.57) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL9702208 0.78 LTA4H (0.50) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL3972186 0.78 LTA4H (0.56) LTA4HTSHRNR1H2BAXMAOA
SCHEMBL1929693 0.78 LTA4H (0.56) LTA4HTSHRNR1H2BAXMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10889690-B2 Siloxane monomers, their polymerization and uses thereof INKRON OY (FI) 2021-01-12 US disclosed
US-10435420-B2 High-RI siloxane monomers, their polymerization and use INKRON OY (FI) 2019-10-08 US disclosed
US-20190225756-A1 Siloxane monomers, their polymerization and uses thereof INKRON OY (FI) 2019-07-25 US disclosed
CN-109715635-A Siloxane monomers, polymerization and use thereof 英克伦股份有限公司 2019-05-03 CN disclosed
US-20180079761-A1 High-RI siloxane monomers, their polymerization and use INKRON OY (FI) 2018-03-22 US disclosed
US-20180079761-A1 High-RI siloxane monomers, their polymerization and use INKRON OY (FI) 2018-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10435420-B2 High-RI siloxane monomers, their polymerization and use IPO9, PPOX, PPID LTA4H 1437/4885TSHR 4556/4885NR1H2 407/4885
US-20180079761-A1 High-RI siloxane monomers, their polymerization and use IPO9, PPOX, PPID LTA4H 1437/4885TSHR 4556/4885NR1H2 407/4885
US-10889690-B2 Siloxane monomers, their polymerization and uses thereof PPOX, PPID, PLOD2 LTA4H 1094/4885TSHR 4777/4885NR1H2 1018/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.