Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003811 | 0.94 | FAAH (0.41) | FAAHMAPTKDM4EALDH1A1ALOX5 | |
| SCHEMBL2006615 | 0.91 | FAAH (0.42) | FAAHMAPTKDM4EALDH1A1ALOX5 | |
| SCHEMBL2009971 | 0.90 | L3MBTL1 (0.37) | FAAHMAPTALDH1A1LMNAALOX12 | |
| SCHEMBL2012375 | 0.89 | FAAH (0.37) | FAAHMAPTPKMGAAKDM4E | |
| SCHEMBL1999493 | 0.89 | FAAH (0.43) | FAAH | |
| SCHEMBL1999528 | 0.89 | ALOX5 (0.37) | FAAHMAPTPKMGAAKDM4E | |
| SCHEMBL2000979 | 0.89 | FAAH (0.45) | FAAHMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL2002842 | 0.88 | MEN1 (0.43) | FAAHMAPTPKMALDH1A1ALOX5 | |
| SCHEMBL2006366 | 0.88 | ALOX5AP (0.40) | FAAHMAPTPKMKDM4EALDH1A1 | |
| SCHEMBL2007820 | 0.86 | LMNA (0.37) | FAAHMAPTPKMGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |