SCHEMBL1999706

SCHEMBL1999706

C=C(/C=C/c1ccccc1)/C=C/c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.58
HDAC3 O15379 2/20 0.58
HDAC4 P56524 2/20 0.58
HDAC1 Q13547 2/20 0.58
HDAC2 Q92769 2/20 0.58
HDAC8 Q9BY41 2/20 0.58
HDAC6 Q9UBN7 2/20 0.58
PLIN1 O60240 2/20 0.58
LMNA P02545 2/20 0.58
RECQL P46063 2/20 0.58
PLIN5 Q00G26 2/20 0.58
ABHD5 Q8WTS1 2/20 0.58
ALDH1A1 P00352 2/20 0.58
F3 P13726 2/20 0.58
TNKS O95271 1/20 0.58
HCAR2 Q8TDS4 1/20 0.58
HDAC7 Q8WUI4 1/20 0.58
HDAC10 Q969S8 1/20 0.58
HDAC11 Q96DB2 1/20 0.58
TNKS2 Q9H2K2 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1999708 1.00 MAPT (0.58) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL3713529 0.89 MAOB (0.58) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL570817 0.88 MAPT (0.52) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL17156438 0.87 ALDH1A1 (0.47) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL12261578 0.84 MAPT (0.58) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL869685 0.84 MAPT (0.58) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL7028129 0.84 ALDH1A1 (0.44) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL4856786 0.82 MAPT (0.56) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL27640189 0.82 MAPT (0.56) MAPTHDAC3HDAC4HDAC1HDAC2
SCHEMBL12252392 0.82 MAPT (0.56) MAPTHDAC3HDAC4HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7960725-B2 Aryl-aryl dendrimers ISIS INNOVATION LIMITED (GB) 2011-06-14 US claimed
US-20100127251-A1 Aryl-Aryl Dendrimers ISIS INNOVATION LIMITED (GB) 2010-05-27 US claimed
US-7632576-B2 Aryl-aryl dendrimers ISIS INNOVATION LIMITED (GB) 2009-12-15 US claimed
US-7537842-B2 Asymmetric dendrimers ISIS INNOVATION LIMITED (GB) 2009-05-26 US claimed
JP-4234434-B2 2009-03-04 JP claimed
EP-1373431-B1 ASYMMETRIC DENDRIMERS ISIS INNOVATION (GB) 2006-10-18 EP claimed
JP-2004534865-A 2004-11-18 JP claimed
US-20040169463-A1 Aryl-aryl dendrimers CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2004-09-02 US claimed
US-20040110029-A1 Asymmetric dendrimers CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2004-06-10 US claimed
EP-1027398-B1 LIGHT-EMITTING DENDRIMERS AND DEVICES ISIS INNOVATION (GB) 2004-06-09 EP claimed
EP-1373431-A1 ASYMMETRIC DENDRIMERS ISIS INNOVATION LIMITED (GB) 2004-01-02 EP claimed
EP-1362382-A1 ARYL-ARYL DENDRIMERS ISIS INNOVATION LIMITED (GB) 2003-11-19 EP claimed
US-20030165716-A1 Dendrimers according to present invention which can be used for incorporation into light emitting devices have core and/or branches comprising electroluminescent or charge-transporting chromophores (conjugated units) CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2003-09-04 US claimed
US-6558818-B1 Light-emitting dendrimers and devices ISIS INNOVATION LTD. (GB) 2003-05-06 US claimed
WO-2002066575-A1 ASYMMETRIC DENDRIMERS ISIS INNOVATION LIMITED (GB) 2002-08-29 WO claimed
WO-2002067343-A1 ARYL-ARYL DENDRIMERS ISIS INNOVATION LIMITED (GB) 2002-08-29 WO claimed
JP-2001521053-A 2001-11-06 JP claimed
EP-1027398-A1 LIGHT-EMITTING DENDRIMERS AND DEVICES ISIS INNOVATION LIMITED (GB) 2000-08-16 EP claimed
WO-1999021935-A1 LIGHT-EMITTING DENDRIMERS AND DEVICES ISIS INNOVATION LIMITED (GB) 1999-05-06 WO claimed
US-8319213-B2 Aryl-aryl dendrimers ISIS INNOVATION LIMITED (GB) 2012-11-27 US disclosed
US-20110272688-A1 ARYL-ARYL DENDRIMERS THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS (GB) 2011-11-10 US disclosed
US-7960725-B2 Aryl-aryl dendrimers ISIS INNOVATION LIMITED (GB) 2011-06-14 US disclosed
US-7960557-B2 Asymmetric dendrimers ISIS INNOVATION LIMITED (GB) 2011-06-14 US disclosed
EP-1254196-B1 DENDRIMERS ISIS INNOVATION (GB) 2010-11-03 EP disclosed
US-20100127251-A1 Aryl-Aryl Dendrimers ISIS INNOVATION LIMITED (GB) 2010-05-27 US disclosed
US-7682708-B2 Dendrimers ISIS INNOVATION LIMITED (GB) 2010-03-23 US disclosed
US-20090326238-A1 ASYMMETRIC DENDRIMERS ISIS INNOVATION LIMITED (GB) 2009-12-31 US disclosed
US-7632576-B2 Aryl-aryl dendrimers ISIS INNOVATION LIMITED (GB) 2009-12-15 US disclosed
US-7537842-B2 Asymmetric dendrimers ISIS INNOVATION LIMITED (GB) 2009-05-26 US disclosed
US-20080004471-A1 Dendrimers OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2008-01-03 US disclosed
US-7276299-B2 Dendrimers ISIS INNOVATION LIMITED (GB) 2007-10-02 US disclosed
US-20060252963-A1 Dendrimers CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2006-11-09 US disclosed
EP-1373431-B1 ASYMMETRIC DENDRIMERS ISIS INNOVATION (GB) 2006-10-18 EP disclosed
US-7083862-B2 Dendrimers ISIS INNOVATION LIMITED (GB) 2006-08-01 US disclosed
US-20040169463-A1 Aryl-aryl dendrimers CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2004-09-02 US disclosed
US-20040110029-A1 Asymmetric dendrimers CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2004-06-10 US disclosed
US-6720093-B2 DEVICE INCORPORATING AS, OR IN, ITS LIGHT-EMITTING ELEMENT LUMINESCENT COMPOUND INCLUDING CONJUGATED DENDRITIC MOLECULAR STRUCTURE COMPRISING GROUPS SELECTED FROM ARYL AND HETEROARYL GROUPS AND ALKENYL GROUPS CONNECTED TO EACH OTHER CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2004-04-13 US disclosed
EP-1373431-A1 ASYMMETRIC DENDRIMERS ISIS INNOVATION LIMITED (GB) 2004-01-02 EP disclosed
EP-1362382-A1 ARYL-ARYL DENDRIMERS ISIS INNOVATION LIMITED (GB) 2003-11-19 EP disclosed
US-20030165716-A1 Dendrimers according to present invention which can be used for incorporation into light emitting devices have core and/or branches comprising electroluminescent or charge-transporting chromophores (conjugated units) CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2003-09-04 US disclosed
US-20030134147-A1 Dendrimers CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) 2003-07-17 US disclosed
US-6558818-B1 Light-emitting dendrimers and devices ISIS INNOVATION LTD. (GB) 2003-05-06 US disclosed
EP-1254196-A1 DENDRIMERS ISIS INNOVATION LIMITED (GB) 2002-11-06 EP disclosed
WO-2002067343-A1 ARYL-ARYL DENDRIMERS ISIS INNOVATION LIMITED (GB) 2002-08-29 WO disclosed
WO-2002066575-A1 ASYMMETRIC DENDRIMERS ISIS INNOVATION LIMITED (GB) 2002-08-29 WO disclosed
WO-2001059030-A1 DENDRIMERS ISIS INNOVATION LIMITED (GB) 2001-08-16 WO disclosed
EP-1027398-A1 LIGHT-EMITTING DENDRIMERS AND DEVICES ISIS INNOVATION LIMITED (GB) 2000-08-16 EP disclosed
WO-1999021935-A1 LIGHT-EMITTING DENDRIMERS AND DEVICES ISIS INNOVATION LIMITED (GB) 1999-05-06 WO disclosed
WO-1999021935-A1 LIGHT-EMITTING DENDRIMERS AND DEVICES ISIS INNOVATION LIMITED (GB) 1999-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100127251-A1 Aryl-Aryl Dendrimers CLTB, AHR, CD22 MAPT 1467/4885HDAC3 148/4885HDAC4 1150/4885
US-20060252963-A1 Dendrimers NPY1R, CHRM1, TLR1 MAPT 771/4885HDAC3 1413/4885HDAC4 3490/4885
US-20030165716-A1 Dendrimers according to present invention which can be used for incorporation into light emitting devices have core and/or branches comprising electroluminescent or charge-transporting chromophores (conjugated units) CLTB, CLTA, CLTC MAPT 572/4885HDAC3 1376/4885HDAC4 2869/4885
US-20080004471-A1 Dendrimers NPY1R, CHRM1, TLR1 MAPT 771/4885HDAC3 1413/4885HDAC4 3490/4885
US-20090326238-A1 ASYMMETRIC DENDRIMERS DNM2, DYNLL2, DNM1 MAPT 286/4885HDAC3 3325/4885HDAC4 4012/4885
US-20110272688-A1 ARYL-ARYL DENDRIMERS CD22, CLTB, AHR MAPT 1266/4885HDAC3 201/4885HDAC4 1264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.