Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23847776 | 0.85 | ACHE (0.41) | TACR1TAAR1GAANPSR1 | |
| SCHEMBL20674858 | 0.84 | TACR1 (0.39) | HTTTACR1TAAR1LMNA | |
| SCHEMBL2758299 | 0.83 | ALDH1A1 (0.45) | HTTTACR1ALDH1A1KDM4EPOLB | |
| SCHEMBL15267204 | 0.74 | TACR1 (0.45) | TACR1ALDH1A1TAAR1KMT2A | |
| SCHEMBL22861119 | 0.74 | PTGS2 (0.41) | ALDH1A1TAAR1CYP19A1 | |
| SCHEMBL11981074 | 0.73 | DAO (0.41) | TACR1ALDH1A1TAAR1CYP19A1SMN1; SMN2 | |
| SCHEMBL13085700 | 0.73 | TACR1 (0.38) | TACR1ALDH1A1TAAR1CYP19A1KMT2A | |
| SCHEMBL24261200 | 0.73 | TACR1 (0.40) | TACR1KMT2AMEN1 | |
| SCHEMBL16503537 | 0.71 | ABCB11 (0.35) | HTTTACR1ALDH1A1KDM4E | |
| SCHEMBL40553 | 0.71 | ALDH1A1 (0.61) | ALDH1A1CYP19A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086767-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086767-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR77 | HTT 1450/4885TACR1 4883/4885ALDH1A1 3489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.