Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002459 | 0.83 | RORC (0.51) | RORCPKM | |
| SCHEMBL20002942 | 0.81 | RORC (0.45) | RORCALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20002321 | 0.81 | CCR5 (0.46) | RORCPKM | |
| SCHEMBL20003053 | 0.81 | CCR5 (0.46) | RORCPKM | |
| SCHEMBL20002221 | 0.81 | RORC (0.45) | RORCL3MBTL1SMN1; SMN2HTTPKM | |
| SCHEMBL20003003 | 0.81 | EPHX2 (0.45) | RORCL3MBTL1PKM | |
| SCHEMBL20002563 | 0.81 | EPHX2 (0.45) | LMNAPOLBALDH1A1L3MBTL1KMT2A | |
| SCHEMBL20003035 | 0.79 | HTR2A (0.44) | RORCL3MBTL1PKM | |
| SCHEMBL20002322 | 0.78 | PKM (0.60) | RORCL3MBTL1SMN1; SMN2KMT2APKM | |
| SCHEMBL20002933 | 0.78 | RORC (0.46) | RORCPOLBL3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |