Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002502 | 0.80 | L3MBTL1 (0.64) | ALDH1A1LMNAL3MBTL1NAMPTRAB9A | |
| SCHEMBL23951553 | 0.77 | ALDH1A1 (0.50) | ALDH1A1LMNANPC1NR2F2NAMPT | |
| SCHEMBL27478359 | 0.77 | ALDH1A1 (0.50) | RORCP2RX7ALDH1A1LMNANPC1 | |
| SCHEMBL30098408 | 0.74 | CCR5 (0.53) | ALDH1A1LMNANPC1HCRTR1HCRTR2 | |
| SCHEMBL23924217 | 0.74 | CCR5 (0.53) | ALDH1A1LMNANPC1HCRTR1HCRTR2 | |
| SCHEMBL20003002 | 0.73 | TSHR (0.48) | RORCALDH1A1L3MBTL1NAMPTRAB9A | |
| SCHEMBL20002837 | 0.72 | RORC (0.49) | RORCALDH1A1NAMPT | |
| SCHEMBL14413535 | 0.71 | EPHX2 (0.47) | RORCL3MBTL1 | |
| SCHEMBL20003085 | 0.71 | PROKR1 (0.44) | L3MBTL1NPC1NAMPTRAB9A | |
| SCHEMBL16886748 | 0.71 | RORC (1.00) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |