Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002837 | 0.87 | RORC (0.49) | RORCNAMPTFNTAFNTBALDH1A1 | |
| SCHEMBL20002502 | 0.83 | L3MBTL1 (0.64) | L3MBTL1MAPK1NAMPTRAB9AALDH1A1 | |
| SCHEMBL20002690 | 0.78 | PRKAA2 (0.50) | RORCALDH1A1SMN1; SMN2 | |
| SCHEMBL20002808 | 0.73 | RORC (0.53) | RORCNAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL13873527 | 0.73 | ALDH1A1 (0.53) | TSHRMAPK1NAMPTRAB9AC3AR1 | |
| SCHEMBL14413535 | 0.73 | EPHX2 (0.47) | RORCL3MBTL1MAPT | |
| SCHEMBL20003091 | 0.73 | RORC (0.54) | RORCL3MBTL1NAMPTRAB9AALDH1A1 | |
| SCHEMBL20002488 | 0.73 | RORC (0.47) | TSHRRORCL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL2606193 | 0.72 | FNTA (0.58) | L3MBTL1NAMPTRAB9AFNTAFNTB | |
| SCHEMBL22493291 | 0.72 | FNTA (0.58) | L3MBTL1NAMPTFNTAFNTBC3AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |