Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18213803 | 0.82 | RIPK1 (0.38) | RORCRIPK1MMP1MMP2MMP9 | |
| SCHEMBL16886251 | 0.81 | RORC (0.35) | RORCRIPK1MMP1MMP2MMP9 | |
| SCHEMBL18799682 | 0.81 | RORC (0.40) | RORCMMP1MMP2MMP9MMP12 | |
| SCHEMBL20002813 | 0.77 | IDO1 (0.53) | RORCRIPK1 | |
| SCHEMBL16886260 | 0.74 | RORC (0.39) | RORCMMP1MMP2 | |
| SCHEMBL20002817 | 0.73 | RORC (0.41) | RORCRIPK1MMP1MMP2MMP9 | |
| SCHEMBL20002774 | 0.72 | ACHE (0.36) | RORC | |
| SCHEMBL20002812 | 0.70 | TAAR1 (0.46) | — | |
| SCHEMBL16892293 | 0.70 | TAAR1 (0.39) | RIPK1MMP1MMP2MMP9MMP12 | |
| SCHEMBL20002194 | 0.69 | KDM1A (0.39) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |