Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20003154 | 0.80 | RORC (0.39) | RAB9ANPC1ATMGRIN1GRIN2B | |
| SCHEMBL20003191 | 0.78 | RORC (0.41) | RAB9ANPC1ATMGRIN1GRIN2B | |
| SCHEMBL20002430 | 0.74 | RORC (0.44) | CCR5KMT2A | |
| SCHEMBL20002823 | 0.74 | CCR5 (0.38) | RAB9ANPC1ATMGRIN1GRIN2B | |
| SCHEMBL20003080 | 0.73 | GRIN1 (0.35) | RAB9ANPC1ATMGRIN1GRIN2B | |
| SCHEMBL20002375 | 0.73 | RORC (0.41) | RAB9ANPC1ATMGRIN1GRIN2B | |
| SCHEMBL20002612 | 0.73 | RORC (0.36) | RAB9ANPC1ATMGRIN1GRIN2B | |
| SCHEMBL20003220 | 0.73 | RORC (0.41) | RAB9ANPC1ATMGRIN1GRIN2B | |
| SCHEMBL20003026 | 0.72 | RORC (0.47) | RAB9ANPC1ATMGRIN1GRIN2B | |
| SCHEMBL20003131 | 0.72 | RORC (0.46) | RAB9ANPC1GRIN1GRIN2BCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092229-B1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-28 | — | — | EP | disclosed |