Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20366552 | 0.81 | ALK (0.34) | ALKKMT2APARP1ALDH1A1MAPK1 | |
| SCHEMBL897525 | 0.81 | ALK (0.43) | ALKALDH1A1MAPK1 | |
| SCHEMBL20004608 | 0.80 | ALK (0.33) | ALKKMT2APARP1ALDH1A1 | |
| SCHEMBL20004206 | 0.79 | ALK (0.38) | ALKKMT2APARP1ALDH1A1MAPK1 | |
| SCHEMBL897012 | 0.78 | HTR2A (0.45) | ALK | |
| SCHEMBL20061137 | 0.78 | S100B (0.38) | ALKKMT2APARP1ALDH1A1MAPK1 | |
| SCHEMBL897888 | 0.77 | TAAR1 (0.39) | ALKKMT2APARP1ALDH1A1MAPK1 | |
| SCHEMBL897378 | 0.76 | ALK (0.43) | ALKKMT2AALDH1A1 | |
| SCHEMBL7805174 | 0.75 | ALK (0.36) | ALKKMT2APARP1 | |
| SCHEMBL20366497 | 0.75 | ALK (0.36) | ALKKMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613729-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |