Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20366552 | 0.91 | ALK (0.34) | ALKSMN1; SMN2ALDH1A1PARP1MAPT | |
| SCHEMBL20004650 | 0.80 | ALK (0.38) | ALKALDH1A1PARP1KMT2A | |
| SCHEMBL897511 | 0.77 | MAPT (0.57) | ALKSMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL20004601 | 0.75 | ALDH1A1 (0.34) | ALKSMN1; SMN2ALDH1A1PARP1MAOA | |
| SCHEMBL20004206 | 0.74 | ALK (0.38) | ALKSMN1; SMN2ALDH1A1PARP1GAA | |
| SCHEMBL20061137 | 0.73 | S100B (0.38) | ALKALDH1A1PARP1MAPTGAA | |
| SCHEMBL897525 | 0.73 | ALK (0.43) | ALKALDH1A1MAPTGAA | |
| SCHEMBL897012 | 0.73 | HTR2A (0.45) | ALK | |
| SCHEMBL27087621 | 0.72 | ALK (0.38) | ALKALDH1A1PARP1GAAMEN1 | |
| SCHEMBL29940534 | 0.72 | ALK (0.38) | ALKALDH1A1PARP1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |