Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19529392 | 0.90 | RAF1 (0.40) | DRD2HTR6L3MBTL1MAPK1ATM | |
| SCHEMBL20008460 | 0.88 | RAF1 (0.41) | DRD2HTR6L3MBTL1MAPK1ATM | |
| SCHEMBL20008122 | 0.78 | SMN1; SMN2 (0.46) | L3MBTL1MAPK1ATMSMN1; SMN2LMNA | |
| SCHEMBL20008452 | 0.76 | GALR2 (0.44) | L3MBTL1MAPK1ATMSMN1; SMN2LMNA | |
| SCHEMBL20009117 | 0.74 | RAF1 (0.40) | L3MBTL1KDM4EGAAACHEALDH1A1 | |
| SCHEMBL20009100 | 0.74 | NUDT1 (0.37) | DRD2HTR6L3MBTL1MAPK1ATM | |
| SCHEMBL20008237 | 0.72 | HRH4 (0.47) | RAF1 | |
| SCHEMBL20008457 | 0.72 | L3MBTL1 (0.34) | L3MBTL1MAPK1ATMSMN1; SMN2LMNA | |
| SCHEMBL20009412 | 0.72 | RAF1 (0.40) | L3MBTL1MAPK1ATMKDM4EGAA | |
| SCHEMBL20009430 | 0.70 | RAF1 (0.49) | L3MBTL1MAPK1ATMKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515446-B1 | THERAPEUTIC COMBINATIONS COMPRISING A RAF INHIBITOR AND A ERK INHIBITOR | NOVARTIS AG (CH) | 2023-12-20 | — | — | EP | disclosed |
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |