Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | CLK3 | P49761 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008452 | 0.74 | GALR2 (0.44) | KMT2AKDM4EGAAL3MBTL1MAPK1 | |
| SCHEMBL20008122 | 0.73 | SMN1; SMN2 (0.46) | RAF1BRAFKMT2AKDM4EGAA | |
| SCHEMBL20008237 | 0.71 | HRH4 (0.47) | RAF1BRAFLRRK2 | |
| SCHEMBL20008538 | 0.70 | DRD2 (0.49) | RAF1ARKMT2AKDM4EGAA | |
| SCHEMBL20008460 | 0.70 | RAF1 (0.41) | RAF1BRAFARKMT2AKDM4E | |
| SCHEMBL20009412 | 0.70 | RAF1 (0.40) | RAF1BRAFARKMT2AKDM4E | |
| SCHEMBL19529392 | 0.70 | RAF1 (0.40) | RAF1BRAFARKMT2AKDM4E | |
| SCHEMBL20010376 | 0.65 | AR (0.53) | RAF1BRAFARATRKMT2A | |
| SCHEMBL2166402 | 0.65 | HRH4 (0.55) | HRH3 | |
| SCHEMBL13575902 | 0.63 | ALDH1A1 (0.43) | ATRKMT2AATRIPKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |