Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.40 |
| ▸ | BRAF | P15056 | 13/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008122 | 0.77 | SMN1; SMN2 (0.46) | RAF1BRAFKDM4EGAAL3MBTL1 | |
| SCHEMBL20008452 | 0.75 | GALR2 (0.44) | KDM4EGAAL3MBTL1MAPK1ATM | |
| SCHEMBL20010376 | 0.74 | AR (0.53) | RAF1BRAFARKDM4EGAA | |
| SCHEMBL20008538 | 0.72 | DRD2 (0.49) | RAF1ARKDM4EGAAL3MBTL1 | |
| SCHEMBL20008460 | 0.72 | RAF1 (0.41) | RAF1BRAFARKDM4EGAA | |
| SCHEMBL20008237 | 0.71 | HRH4 (0.47) | RAF1BRAFCNR2 | |
| SCHEMBL19529392 | 0.71 | RAF1 (0.40) | RAF1BRAFARKDM4EGAA | |
| SCHEMBL20009430 | 0.70 | RAF1 (0.49) | RAF1BRAFARKDM4EGAA | |
| SCHEMBL20010344 | 0.68 | NUDT1 (0.51) | RAF1BRAFKDM4EGAAKMT2A | |
| SCHEMBL20009114 | 0.66 | BRAF (0.57) | RAF1BRAFAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |