Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19529392 | 0.99 | RAF1 (0.40) | RAF1DRD2HTR6MAPK1L3MBTL1 | |
| SCHEMBL20008538 | 0.88 | DRD2 (0.49) | RAF1DRD2HTR6MAPK1L3MBTL1 | |
| SCHEMBL20008122 | 0.75 | SMN1; SMN2 (0.46) | RAF1MAPK1L3MBTL1ATMKMT2A | |
| SCHEMBL20008452 | 0.73 | GALR2 (0.44) | MAPK1L3MBTL1ATMKMT2ASMN1; SMN2 | |
| SCHEMBL20009412 | 0.72 | RAF1 (0.40) | RAF1MAPK1L3MBTL1ATMKMT2A | |
| SCHEMBL20009430 | 0.70 | RAF1 (0.49) | RAF1MAPK1L3MBTL1ATMKMT2A | |
| SCHEMBL20009117 | 0.70 | RAF1 (0.40) | RAF1L3MBTL1BRAFKDM4EGAA | |
| SCHEMBL20008237 | 0.70 | HRH4 (0.47) | RAF1BRAFMAPK14 | |
| SCHEMBL20008457 | 0.68 | L3MBTL1 (0.34) | RAF1MAPK1L3MBTL1ATMKMT2A | |
| SCHEMBL20010376 | 0.67 | AR (0.53) | RAF1KMT2AARSMN1; SMN2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |