Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21954796 | 0.60 | SMN1; SMN2 (0.38) | KMT2AALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL19187802 | 0.59 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL20008169 | 0.58 | PABPC1 (0.34) | PABPC1 | |
| SCHEMBL20008233 | 0.56 | RAB9A (0.39) | KMT2AALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL14595482 | 0.56 | SMN1; SMN2 (0.36) | KMT2AALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL22225558 | 0.55 | ALDH1A1 (0.35) | KMT2AALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL8312462 | 0.54 | GAA (0.73) | KMT2AALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL10246156 | 0.54 | PHGDH (0.63) | KMT2AALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL16488283 | 0.54 | TERT (0.33) | SMN1; SMN2 | |
| SCHEMBL20009403 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |