Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 4/20 | 0.33 |
| ▸ | CES1 | P23141 | 4/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004659 | 0.95 | KDM4E (0.37) | ALDH1A1LMNAMAPTALOX12KDM4E | |
| SCHEMBL2003477 | 0.92 | LMNA (0.40) | ALDH1A1LMNAMAPTALOX12KDM4E | |
| SCHEMBL2001936 | 0.92 | OPRK1 (0.36) | ALDH1A1LMNAMAPTALOX12KDM4E | |
| SCHEMBL2002177 | 0.91 | MAPT (0.38) | ALDH1A1LMNAMAPTKDM4EOPRK1 | |
| SCHEMBL2003372 | 0.90 | PLA2G2A (0.38) | MAPTKDM4EOPRK1CYP1A2CYP2D6 | |
| SCHEMBL2002081 | 0.90 | L3MBTL1 (0.35) | L3MBTL1ALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL2005259 | 0.90 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL2004340 | 0.89 | F2RL3 (0.37) | LMNAMAPTKDM4EOPRK1FAAH | |
| SCHEMBL2005140 | 0.89 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1LMNAMAPTALOX12 | |
| SCHEMBL1999915 | 0.88 | L3MBTL1 (0.39) | L3MBTL1ALDH1A1LMNAMAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |