Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA3 | P07451 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA6 | P23280 | 2/20 | 0.35 |
| ▸ | CA5A | P35218 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL29625939 | 0.75 | — | — | |
| Potassium Ion SCHEMBL2004450 | 0.75 | CA12 (0.52) | CA12CA1CA2CA3CA4 | |
| Potassium Ion SCHEMBL8214640 | 0.71 | NFKB1 (0.30) | NFKB1 | |
| SCHEMBL21748449 | 0.69 | NFKB1 (0.40) | NFKB1CA12CA1CA2CA3 | |
| SCHEMBL8666930 | 0.69 | — | — | |
| SCHEMBL8666193 | 0.69 | — | — | |
| SCHEMBL29674792 | 0.69 | — | — | |
| SCHEMBL29625938 | 0.69 | — | — | |
| SCHEMBL21748451 | 0.67 | NFKB1 (0.46) | NFKB1CA12CA1CA2CA3 | |
| Potassium Ion SCHEMBL30966242 | 0.67 | TSHR (0.38) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212271-A1 | HYDROPHILIC COMPOSITIONS, METHODS FOR THEIR PRODUCTION, AND SUBSTRATES COATED WITH SUCH COMPOSITIONS | PPG INDUSTRIES OHIO, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| US-7959980-B2 | Hydrophilic compositions, methods for their production, and substrates coated with such compositions | PPG INDUSTRIES OHIO, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7354650-B2 | Multi-layer coatings with an inorganic oxide network containing layer and methods for their application | PPG INDUSTRIES OHIO, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| EP-1749066-A1 | HYDROPHILIC COMPOSITIONS, METHODS FOR THEIR PRODUCTION, AND SUBSTRATES COATED WITH SUCH COMPOSITIONS | PPG Industries Ohio, Inc. (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005118724-A1 | HYDROPHILIC COMPOSITIONS, METHODS FOR THEIR PRODUCTION, AND SUBSTRATES COATED WITH SUCH COMPOSITIONS | PPG INDUSTRIES OHIO, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20050266981-A1 | Hydrophilic compositions, methods for their production, and substrates coated with such compositions | PPG INDUSTRIES OHIO, INC. | 2005-12-01 | — | — | US | disclosed |
| US-20050266235-A1 | Multi-layer coatings with an inorganic oxide network containing layer and methods for their application | PPG INDUSTRIES OHIO, INC. | 2005-12-01 | — | — | US | disclosed |
| US-4383866-A | Metal condensed phosphate hardener coated with reaction product from a metal aluminate and/or a metal borate | PPG INDUSTRIES, INC. (US) | 1983-05-17 | — | — | US | disclosed |
| US-4375496-A | Metal condensed phosphate hardener coated with reaction product from a metal aluminate and/or a metal borate | PPG INDUSTRIES, INC. (US) | 1983-03-01 | — | — | US | disclosed |
| US-4328033-A | Curable silicate composition containing metal condensed phosphate hardener coated with reaction product from a metal aluminate and/or a metal borate | PPG INDUSTRIES, INC. (US) | 1982-05-04 | — | — | US | disclosed |
| US-4319926-A | DURABLE PROTECTIVE COATINGS | PPG INDUSTRIES, INC. (US) | 1982-03-16 | — | — | US | disclosed |
| US-4318743-A | INCLUDING A BASE HAVING A GREATER DEGREE OF BASICITY THAN THE GLASS SILICATE; WATERBASE PAINTS; UNIFORM DISPERSION | PPG INDUSTRIES, INC. (US) | 1982-03-09 | — | — | US | disclosed |