Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.52 |
| ▸ | CA6 | P23280 | 5/20 | 0.52 |
| ▸ | CA7 | P43166 | 5/20 | 0.52 |
| ▸ | CA9 | Q16790 | 5/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA4 | P22748 | 4/20 | 0.52 |
| ▸ | CA5A | P35218 | 4/20 | 0.52 |
| ▸ | CA3 | P07451 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL2002335 | 0.75 | NFKB1 (0.38) | CA12CA6CA7CA9CA14 | |
| SCHEMBL29966585 | 0.75 | CA12 (0.67) | CA12CA6CA7CA9CA14 | |
| SCHEMBL28525945 | 0.73 | CA12 (0.69) | CA12CA6CA7CA9CA14 | |
| SCHEMBL31523917 | 0.72 | CA12 (0.55) | CA12CA6CA7CA9CA14 | |
| SCHEMBL5577158 | 0.72 | CA12 (0.55) | CA12CA6CA7CA9CA14 | |
| SCHEMBL3802347 | 0.72 | CA12 (0.55) | CA12CA6CA7CA9CA14 | |
| SCHEMBL231988 | 0.72 | CA12 (0.55) | CA12CA6CA7CA9CA14 | |
| SCHEMBL345134 | 0.71 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL26667 | 0.71 | CA12 (0.85) | CA12CA6CA7CA9CA14 | |
| SCHEMBL15381 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212271-A1 | HYDROPHILIC COMPOSITIONS, METHODS FOR THEIR PRODUCTION, AND SUBSTRATES COATED WITH SUCH COMPOSITIONS | PPG INDUSTRIES OHIO, INC. (US) | 2011-09-01 | — | — | US | disclosed |
| US-7959980-B2 | Hydrophilic compositions, methods for their production, and substrates coated with such compositions | PPG INDUSTRIES OHIO, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7354650-B2 | Multi-layer coatings with an inorganic oxide network containing layer and methods for their application | PPG INDUSTRIES OHIO, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-7354624-B2 | Applying a photocatalytic liquid and a hydrophilic, ungelled, completely hydrolyzed organosilicate binder directly to the surface of a painted article and curing to form an anti-fouling and/or self-cleaning coating having a dry film thickness of no more than 200 nanometers | PPG INDUSTRIES OHIO, INC. (US) | 2008-04-08 | — | — | US | disclosed |
| US-20050266981-A1 | Hydrophilic compositions, methods for their production, and substrates coated with such compositions | PPG INDUSTRIES OHIO, INC. | 2005-12-01 | — | — | US | disclosed |
| US-20050266248-A1 | Multi-layer coatings and related methods | PPG INDUSTRIES OHIO, INC. | 2005-12-01 | — | — | US | disclosed |
| US-20050266235-A1 | Multi-layer coatings with an inorganic oxide network containing layer and methods for their application | PPG INDUSTRIES OHIO, INC. | 2005-12-01 | — | — | US | disclosed |
| US-4383866-A | Metal condensed phosphate hardener coated with reaction product from a metal aluminate and/or a metal borate | PPG INDUSTRIES, INC. (US) | 1983-05-17 | — | — | US | disclosed |
| US-4375496-A | Metal condensed phosphate hardener coated with reaction product from a metal aluminate and/or a metal borate | PPG INDUSTRIES, INC. (US) | 1983-03-01 | — | — | US | disclosed |
| US-4328033-A | Curable silicate composition containing metal condensed phosphate hardener coated with reaction product from a metal aluminate and/or a metal borate | PPG INDUSTRIES, INC. (US) | 1982-05-04 | — | — | US | disclosed |
| US-4319926-A | DURABLE PROTECTIVE COATINGS | PPG INDUSTRIES, INC. (US) | 1982-03-16 | — | — | US | disclosed |
| US-4318743-A | INCLUDING A BASE HAVING A GREATER DEGREE OF BASICITY THAN THE GLASS SILICATE; WATERBASE PAINTS; UNIFORM DISPERSION | PPG INDUSTRIES, INC. (US) | 1982-03-09 | — | — | US | disclosed |