Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007363 | 0.93 | ALOX5AP (0.40) | HSD17B10MAPTPPARGALOX15ALOX12 | |
| SCHEMBL2001978 | 0.92 | FAAH (0.45) | HSD17B10MAPTALOX15ALOX12MEN1 | |
| SCHEMBL2004625 | 0.92 | CYP2C9 (0.40) | MAPTALOX12CYP3A4TSHRKMT2A | |
| SCHEMBL2003496 | 0.91 | ALDH1A1 (0.40) | MEN1CYP3A4KMT2AMAPK1LMNA | |
| SCHEMBL2012906 | 0.91 | MAPT (0.44) | HSD17B10MAPTPPARGALOX15ALOX12 | |
| SCHEMBL2005932 | 0.90 | MEN1 (0.46) | MAPTMEN1CYP3A4TSHRKMT2A | |
| SCHEMBL2004973 | 0.89 | PTGES2 (0.42) | HSD17B10MAPTPPARGALOX15ALOX12 | |
| SCHEMBL2003159 | 0.89 | ALOX5AP (0.46) | HSD17B10MAPTMEN1CYP3A4TSHR | |
| SCHEMBL2003925 | 0.88 | ALOX5 (0.39) | HSD17B10MAPTPPARGALOX15ALOX12 | |
| SCHEMBL2004901 | 0.87 | MAPT (0.36) | HSD17B10MAPTPPARGALOX15ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |