Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006285 | 0.93 | HSD17B10 (0.39) | ALOX5APALOX5MAPTALDH1A1KDM4E | |
| SCHEMBL2004791 | 0.91 | MAPT (0.44) | ALOX5APMAPTPKMGAAALDH1A1 | |
| SCHEMBL2003297 | 0.91 | L3MBTL1 (0.38) | ALOX5APALOX5MAPTGAAALDH1A1 | |
| SCHEMBL2003239 | 0.90 | PTGES2 (0.41) | ALOX5APALOX5MAPTPKMGAA | |
| SCHEMBL2001978 | 0.90 | FAAH (0.45) | ALOX5APALOX5MAPTGAAALDH1A1 | |
| SCHEMBL2002225 | 0.88 | ALOX5AP (0.39) | ALOX5APALOX5MAPTPKMGAA | |
| SCHEMBL2003496 | 0.88 | ALDH1A1 (0.40) | ALDH1A1KDM4ELMNAMAPK1MEN1 | |
| SCHEMBL2006664 | 0.88 | ALOX5AP (0.36) | ALOX5APALOX5MAPTPKMGAA | |
| SCHEMBL2005932 | 0.87 | MEN1 (0.46) | ALOX5APALOX5MAPTPKMALDH1A1 | |
| SCHEMBL2003159 | 0.87 | ALOX5AP (0.46) | ALOX5APALOX5MAPTPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |