Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 6/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011328 | 0.93 | LMNA (0.40) | ALOX5APSLC26A4POLBLMNASMN1; SMN2 | |
| SCHEMBL2003542 | 0.93 | MAPT (0.39) | ALOX5APALOX5F10LMNAMAPT | |
| SCHEMBL2003159 | 0.92 | ALOX5AP (0.46) | ALOX5APALOX5LMNASMN1; SMN2MAPT | |
| SCHEMBL2006172 | 0.92 | ALOX5AP (0.39) | ALOX5APALOX5SLC26A4POLBLMNA | |
| SCHEMBL2004625 | 0.91 | CYP2C9 (0.40) | ALOX5APALOX5F10LMNAMAPT | |
| SCHEMBL2006586 | 0.90 | ALOX5AP (0.39) | ALOX5APALOX5F10SLC26A4POLB | |
| SCHEMBL2005115 | 0.90 | ALOX5AP (0.37) | ALOX5APALOX5F10SLC26A4POLB | |
| SCHEMBL2012281 | 0.89 | FAAH (0.38) | ALOX5APALOX5LMNASMN1; SMN2MAPT | |
| SCHEMBL2003297 | 0.88 | L3MBTL1 (0.38) | ALOX5APALOX5F10LMNASMN1; SMN2 | |
| SCHEMBL2007246 | 0.88 | LMNA (0.38) | ALOX5APALOX5SLC26A4POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |