SCHEMBL20031890

SCHEMBL20031890

N#Cc1c(C#N)c2c(c3c1CCc1ccccc1-3)-c1ccc(OCCCCCC=O)cc1CC2

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.38
HSD11B1 P28845 1/20 0.36
HSD11B2 P80365 1/20 0.36
MAOA P21397 2/20 0.36
EGFR P00533 2/20 0.36
KDM4E B2RXH2 2/20 0.35
GLA P06280 1/20 0.35
MAPK1 P28482 2/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TP53 P04637 1/20 0.35
POLB P06746 1/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
HRH3 Q9Y5N1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20031911 0.95 MAOB (0.41) MAOBMAOAEGFRMAPK1HRH3
SCHEMBL20031909 0.90 MAOB (0.43) MAOBMAOAEGFRMAPK1HRH3
SCHEMBL20031650 0.90 MAOB (0.38) MAOBMAOAEGFRMAPK1HRH3
SCHEMBL20031873 0.90 MAOB (0.38) MAOBEGFRHRH3
SCHEMBL20031904 0.90 THRA (0.43) MAOBEGFRKDM4EMEN1ALDH1A1
SCHEMBL22683257 0.89 MAOB (0.39) MAOBMAOAEGFRMEN1ALDH1A1
SCHEMBL20031661 0.84 KDM4E (0.42) MAOBEGFRKDM4EGLAMAPK1
SCHEMBL20031901 0.83 HSD11B1 (0.33) HSD11B1HSD11B2KDM4EGLAMAPK1
SCHEMBL22703025 0.82 PPARA (0.33) MAOBHSD11B1HSD11B2EGFRKDM4E
SCHEMBL22703003 0.81 ITGB3 (0.38) MAOBEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3518746-B1 [5]HELICENE DERIVATIVES AS MOLECULAR REPORTERS FOR DIAGNOSTIC APPLICATIONS AND METHODS OF SYNTHESIS THEREFOR NATIONAL SCIENCE AND TECH DEVELOPMENT AGENCY (TH) 2020-11-25 EP disclosed
WO-2018063105-A1 [5]HELICENE DERIVATIVES AS MOLECULAR REPORTERS FOR DIAGNOSTIC APPLICATIONS AND METHODS OF SYNTHESIS THEREFOR NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (TH) 2018-04-05 WO disclosed