Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GPR39 | O43194 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000835 | 0.94 | PLA2G2A (0.38) | ALOX5APF2RL3MAPTGRM5GPR39 | |
| SCHEMBL2004941 | 0.92 | GRM5 (0.38) | LMNASMN1; SMN2MAPTGRM5GPR39 | |
| SCHEMBL2004879 | 0.91 | ALOX5AP (0.33) | ALOX5APLMNASMN1; SMN2F2RL3MAPT | |
| SCHEMBL2006974 | 0.91 | LMNA (0.38) | ALOX5APLMNASMN1; SMN2MAPTGRM5 | |
| SCHEMBL2006492 | 0.90 | GRM5 (0.35) | ALOX5APLMNASMN1; SMN2MAPTGRM5 | |
| SCHEMBL2002391 | 0.89 | L3MBTL1 (0.39) | ALOX5APLMNASMN1; SMN2MAPTGRM5 | |
| SCHEMBL2002093 | 0.89 | LMNA (0.40) | LMNASMN1; SMN2MAPTGRM5GPR39 | |
| SCHEMBL2003150 | 0.89 | S1PR1 (0.35) | ALOX5APLMNASMN1; SMN2F2RL3MAPT | |
| SCHEMBL2007600 | 0.88 | S1PR1 (0.40) | ALOX5APLMNASMN1; SMN2F2RL3MAPT | |
| SCHEMBL2004340 | 0.87 | F2RL3 (0.37) | ALOX5APLMNASMN1; SMN2F2RL3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |