Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002685 | 0.94 | PLA2G2A (0.37) | ALOX5APCYP3A4CYP2C9F2RL3LMNA | |
| SCHEMBL2005091 | 0.92 | ALOX5AP (0.39) | ALOX5APALOX5STAT3 | |
| SCHEMBL2005893 | 0.92 | SCD (0.34) | CYP3A4CYP2C9LMNAMAPTSCD | |
| SCHEMBL2003268 | 0.91 | ALOX5AP (0.36) | ALOX5APCYP3A4CYP2C9F2RL3LMNA | |
| SCHEMBL2003150 | 0.91 | S1PR1 (0.35) | ALOX5APCYP3A4CYP2C9F2RL3LMNA | |
| SCHEMBL2002148 | 0.91 | LMNA (0.34) | ALOX5APCYP3A4CYP2C9LMNAMAPT | |
| SCHEMBL2009499 | 0.90 | FAAH (0.33) | CYP3A4CYP2C9LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2005962 | 0.89 | L3MBTL1 (0.35) | LMNAMAPTSCDSCD5 | |
| SCHEMBL2002732 | 0.88 | LMNA (0.33) | ALOX5APCYP3A4CYP2C9F2RL3LMNA | |
| SCHEMBL2005502 | 0.88 | LMNA (0.38) | CYP3A4CYP2C9LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |