Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GPR39 | O43194 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | VDR | P11473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002391 | 0.95 | L3MBTL1 (0.39) | GRM5FAAHCES1TSHRLMNA | |
| SCHEMBL2002093 | 0.95 | LMNA (0.40) | GRM5FAAHCES1TSHRLMNA | |
| SCHEMBL2006492 | 0.95 | GRM5 (0.35) | GRM5FAAHCES1TSHRLMNA | |
| SCHEMBL2000835 | 0.93 | PLA2G2A (0.38) | GRM5MAPTCYP2C9CYP1A2CYP2D6 | |
| SCHEMBL2003268 | 0.92 | ALOX5AP (0.36) | GRM5FAAHCES1LMNAMAPT | |
| SCHEMBL2005893 | 0.90 | SCD (0.34) | TSHRLMNAMAPTALDH1A1ALOX12 | |
| SCHEMBL2004149 | 0.89 | GRM5 (0.41) | GRM5FAAHCES1TSHRLMNA | |
| SCHEMBL2005502 | 0.87 | LMNA (0.38) | TSHRLMNAMAPTALDH1A1GRM4 | |
| SCHEMBL1999445 | 0.86 | GRM5 (0.41) | GRM5FAAHCES1TSHRLMNA | |
| SCHEMBL2001648 | 0.86 | RET (0.37) | TSHRLMNAMAPTALDH1A1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |