SCHEMBL200337

SCHEMBL200337

FC(F)(F)C(F)(F)C1CC2C=CC1C2

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32
ALDH1A1 P00352 2/20 0.31
TDP1 Q9NUW8 2/20 0.31
GAA P10253 1/20 0.31
USP2 O75604 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4415495 0.84 KDM4E (0.31) KDM4ELMNAALDH1A1TDP1GAA
SCHEMBL17629736 0.83 LMNA (0.31) LMNA
SCHEMBL17642429 0.83 LMNA (0.31) LMNA
SCHEMBL10714009 0.83 LMNA (0.31) LMNA
SCHEMBL7048034 0.82 ALDH1A1 (0.35) KDM4ELMNAALDH1A1TDP1GAA
SCHEMBL11921079 0.82 ALDH1A1 (0.35) KDM4ELMNAALDH1A1TDP1USP2
SCHEMBL15362615 0.80
SCHEMBL24643274 0.80 LMNA (0.34) KDM4ELMNAALDH1A1TDP1GAA
SCHEMBL203770 0.80 LMNA (0.34) KDM4ELMNAALDH1A1TDP1GAA
SCHEMBL75227 0.77 ALDH1A1 (0.35) KDM4ELMNAALDH1A1TDP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3197881-B1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM PROMERUS LLC (US) 2020-04-29 EP claimed
US-10303060-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2019-05-28 US claimed
US-20180186747-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM PROMERUS, LLC (US) 2018-07-05 US claimed
US-9938241-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2018-04-10 US claimed
US-9610549-B2 Polycyclo-olefinic block copolymers PROMERUS, LLC (US) 2017-04-04 US claimed
US-20160238931-A1 PHOTOIMAGEABLE COMPOSITIONS CONTAINING PHOTOBASE GENERATORS SUMITOMO BAKELITE CO., LTD. (JP) 2016-08-18 US claimed
US-20160147145-A1 PHOTOIMAGEABLE COMPOSITIONS CONTAINING OXETANE FUNCTIONALITY PROMERUS, LLC 2016-05-26 US claimed
US-20160083352-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM SUMITOMO BAKELITE CO., LTD. (JP) 2016-03-24 US claimed
US-20160046752-A1 POLYCYCLO-OLEFINIC BLOCK COPOLYMERS SUMITOMO BAKELITE CO., LTD. (JP) 2016-02-18 US claimed
US-7101496-B2 Thermoplastic norbornene resin based optical film JSR CORPORATION (JP) 2006-09-05 US claimed
CN-117586452-A Cycloolefin composition and optical resin material 杭州睿丰融创科技有限公司 2024-02-23 CN disclosed
EP-3197881-B1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM PROMERUS LLC (US) 2020-04-29 EP disclosed
US-10303060-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2019-05-28 US disclosed
US-10245562-B2 Pervaporation membranes derived from polycyclo-olefinic block copolymers PROMERUS, LLC (US) 2019-04-02 US disclosed
WO-2018148479-A1 PHOTOALIGNMENT FILM FORMING COMPOSITION AND LCD DEVICES DERIVED THEREFROM PROMERUS, LLC (US) 2018-08-16 WO disclosed
US-20040047056-A1 Thermoplastic norbornene resin based optical film JSR CORPORATION (JP) 2004-03-11 US disclosed
EP-1395855-A2 THERMOPLASTIC NORBORNENE RESIN BASED OPTICAL FILM JSR Corporation (JP) 2004-03-10 EP disclosed
WO-2002088783-A1 THERMOPLASTIC NORBORNENE RESIN BASED OPTICAL FILM JSR CORPORATION (JP) 2002-11-07 WO disclosed
WO-2002088784-A2 THERMOPLASTIC NORBORNENE RESIN BASED OPTICAL FILM JSR CORPORATION (JP) 2002-11-07 WO disclosed
US-6447868-B1 INJECTION MOLDING MATERIAL COMPRISING A CYCLIC POLYOLEFIN RESIN HAVING A GLASS TRANSITION TEMPERATURE OF 120 C TO 170 C; POLYALKENAMERS JSR CORPORATION (JP) 2002-09-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160083352-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM RDX, AOX1, ALDH1A2 KDM4E 2719/4885LMNA 1931/4885ALDH1A1 24/4885
US-10245562-B2 Pervaporation membranes derived from polycyclo-olefinic block copolymers VAPB, NOTUM, VAPA KDM4E 2930/4885LMNA 2144/4885ALDH1A1 2150/4885
US-20180186747-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM ZYX, AOX1, RDX KDM4E 1745/4885LMNA 1545/4885ALDH1A1 145/4885
US-10303060-B2 Diazirine compounds and compositions derived therefrom ZYX, AOX1, RDX KDM4E 1745/4885LMNA 1545/4885ALDH1A1 145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.