Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20043028 | 0.90 | KDM4E (0.40) | KDM4EHPGDTSHRCASP1CASP7 | |
| SCHEMBL20042689 | 0.90 | P2RX7 (0.39) | CASP1CASP7HSD17B10P2RX7TP53 | |
| SCHEMBL20042713 | 0.88 | GRM5 (0.45) | KDM4EHPGDTSHRCASP1CASP7 | |
| SCHEMBL20042854 | 0.87 | GRM5 (0.42) | KDM4EHPGDTSHRCASP1CASP7 | |
| SCHEMBL20042721 | 0.85 | GRM5 (0.47) | MEN1KMT2AP2RX7L3MBTL1GRM5 | |
| SCHEMBL20042863 | 0.85 | GRM5 (0.42) | P2RX7TP53THRBTDP1GRM5 | |
| SCHEMBL20042728 | 0.85 | MEN1 (0.42) | MEN1KMT2AALDH1A1GPR6L3MBTL1 | |
| SCHEMBL20042821 | 0.82 | MEN1 (0.41) | KDM4EHPGDTSHRCASP1CASP7 | |
| SCHEMBL20042733 | 0.82 | MEN1 (0.41) | KDM4EHPGDTSHRCASP1CASP7 | |
| SCHEMBL20042702 | 0.82 | P2RX7 (0.49) | TSHRHSD17B10MEN1KMT2AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |