Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | CASP1 | P29466 | 4/20 | 0.40 |
| ▸ | CASP7 | P55210 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | CFTR | P13569 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042656 | 0.90 | KDM4E (0.37) | KDM4ETSHRCASP1CASP7HSD17B10 | |
| SCHEMBL20042713 | 0.90 | GRM5 (0.45) | KDM4ETSHRCASP1CASP7HSD17B10 | |
| SCHEMBL20042721 | 0.87 | GRM5 (0.47) | KMT2AMEN1CFTRL3MBTL1P2RX7 | |
| SCHEMBL20042728 | 0.86 | MEN1 (0.42) | KMT2AMEN1ALDH1A1L3MBTL1FASN | |
| SCHEMBL20042854 | 0.84 | GRM5 (0.42) | KDM4ETSHRCASP1CASP7HSD17B10 | |
| SCHEMBL20042743 | 0.82 | P2RX7 (0.40) | KDM4ETSHRCASP1CASP7HSD17B10 | |
| SCHEMBL20042903 | 0.82 | MEN1 (0.42) | KDM4ETSHRCASP1CASP7HSD17B10 | |
| SCHEMBL20042707 | 0.81 | P2RX7 (0.40) | KDM4ETSHRCASP1CASP7HSD17B10 | |
| SCHEMBL20042873 | 0.81 | P2RX7 (0.38) | KDM4ETSHRCASP1CASP7HSD17B10 | |
| SCHEMBL20042668 | 0.81 | HPGD (0.51) | KDM4EHPGDKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |