Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042796 | 0.89 | P2RX7 (0.38) | KDM4ERECQLP2RX7KMT2AMEN1 | |
| SCHEMBL20042684 | 0.85 | SMN1; SMN2 (0.52) | KDM4EP2RX7HTTALDH1A1HPGD | |
| SCHEMBL20042917 | 0.85 | P2RX7 (0.39) | KDM4EP2RX7HTTNPSR1 | |
| SCHEMBL20042668 | 0.85 | HPGD (0.51) | KDM4EP2RX7KMT2AMEN1HTT | |
| SCHEMBL20042653 | 0.84 | P2RX7 (0.37) | KDM4ERECQLP2RX7HPGD | |
| SCHEMBL20042911 | 0.84 | P2RX7 (0.39) | KDM4EP2RX7KMT2AMEN1HTT | |
| SCHEMBL20042771 | 0.83 | P2RX7 (0.47) | KDM4EP2RX7KMT2AMEN1HTT | |
| SCHEMBL20042721 | 0.82 | GRM5 (0.47) | P2RX7KMT2AMEN1CFTRL3MBTL1 | |
| SCHEMBL20042652 | 0.82 | P2RX7 (0.66) | KDM4EP2RX7KMT2AMEN1GAA | |
| SCHEMBL20042839 | 0.82 | P2RX7 (0.45) | KDM4EP2RX7KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |